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Anti-FGG antibody [5A6] (STJ98071) STJ98071|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-FGG antibody [5A6] (STJ98071)

  • 產品型號：STJ98071
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-FGG antibody [5A6] (STJ98071)
詳情介紹：
Host: Mouse
Applications: WB/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Fibrinogen gamma chain is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 5A6
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FGG
Gene ID: 2266
Uniprot ID: FIBG_HUMAN
Specificity: Fibrinogen Gamma Monoclonal Antibody detects endogenous levels of Fibrinogen Gamma protein.
Immunogen: Purified recombinant fragment of human Fibrinogen Gamma expressed in E. Coli.
Post Translational Modifications Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin.
Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name Fibrinogen Gamma Chain
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1236974
Reactome: R-HSA-140875
Reactome: R-HSA-166058
Reactome: R-HSA-216083
Reactome: R-HSA-354192
Reactome: R-HSA-354194
Reactome: R-HSA-372708
Reactome: R-HSA-381426
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5674135
Reactome: R-HSA-5686938
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-8957275
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Secreted
Alternative Antibody Names Anti-Fibrinogen Gamma Chain antibody
Anti-FGG antibody
Anti-PRO2061 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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