Anti-Fibronectin antibody [568] (STJ16100986) STJ16100986|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-Fibronectin antibody [568] (STJ16100986)
產品型號：STJ16100986
產品廠商：ST john's laboratory
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簡單介紹：

Anti-Fibronectin antibody [568] (STJ16100986)

詳情介紹：

Host:	Mouse
Applications:	FC/WB/IF/IHC
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Fibronectin is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	568
Conjugation:	Unconjugated
Isotype:	IgG1k
Formulation:	PBS with 0.02% Sodium Azide.
Purification:	Affinity purified from tissue culture.
Concentration:	Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range:	Flow cytometry (1-2 µg/million cells in 0, 1 ml). Immunoblotting (1 µg/ml for 2h at RT). Immunofluorescence (1-2 µg/ml). Immunohistology (1-2 µg/ml for 30-60 min at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris
Storage Instruction:	Store for up to 1 year at 2-8°C upon receipt.

Gene Symbol:	FN1
Gene ID:	2335
Uniprot ID:	FINC_HUMAN
Immunogen:	A BALB/c mouse was immunized with a high molecular fraction of proteins secreted by cultured human fibroblasts.Fusion partner: P3-C63-Ag8.653.

Tissue Specificity	Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
Post Translational Modifications	Sulfated. It is not known whether both or only one of Thr-2155 and Thr-2156 are/is glycosylated. Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers). Phosphorylated by FAM20C in the extracellular medium. Proteolytic processing produces the C-terminal NC1 peptide, anastellin. Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation. Serotonylated on Gln residues by TGM2 in response to hypoxia.
Function	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. Anastellin: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.
Protein Name	Fibronectin Fn Cold-Insoluble Globulin Cig Cleaved Into - Anastellin - Ugl-Y1 - Ugl-Y2 - Ugl-Y3
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1474228 Reactome: R-HSA-1474244 Reactome: R-HSA-1566977 Reactome: R-HSA-202733 Reactome: R-HSA-2129379 Reactome: R-HSA-216083 Reactome: R-HSA-3000170 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-381426 Reactome: R-HSA-5674135 Reactome: R-HSA-6785807 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8874081 Reactome: R-HSA-8957275 Reactome: R-HSA-9634597 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9700645 Reactome: R-HSA-9725370 Reactome: R-HSA-9725371
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Fibronectin antibody Anti-Fn antibody Anti-Cold-Insoluble Globulin antibody Anti-Cig Cleaved Into - Anastellin - Ugl-Y1 - Ugl-Y2 - Ugl-Y3 antibody Anti-FN1 antibody Anti-FN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-Fibronectin antibody [568] (STJ16100986)